Dengue Vaccines Development Is Challenging As the Virus Has Four Different Serotypes Antigenically and Companies Are Acquiring To Develop Vaccines Ideal For All The Serotypes

 

Dengue Vaccines Market
Dengue Vaccines

Vaccines have shown to be an excellent option for preventing dengue. There are several dengue vaccines currently available in the market, each having a different efficacy and safety profile.

The development of a dengue vaccine is critical in preventing dengue. The World Health Organization has listed dengue as one of world's top global health threats. Vaccines that protect against dengue are not yet ready for mass vaccination. Whereas there is no single vaccine, there are several promising candidates in development. The development of new vaccines has accelerated in recent years, and Sanofi Pasteur has already announced that its Dengvaxia(r) vaccine which has been approved for use in 20 countries.

The Global Dengue Vaccine Market is estimated to account for US$ 1,262.0 Mn in terms of value by the end of 2027.

The approval of a dengue vaccine depends on several factors. It is crucial to ensure that the vaccine is suitable for the recipient. For example, a patient must have had a previous infection with DENV or have an anti-DENV antibody level that is higher than 0.10. Serodiagnostic tests for children are available to help determine whether or not the vaccine is suitable. The results must be reviewed within five days after vaccination.

The Food and Drug Administration (FDA) recently approved the first dengue vaccine, Dengvaxia, for children nine and older who live in countries with high dengue activity. The vaccine has been approved for children with laboratory-confirmed previous DENV infection. Multiple dengue vaccine candidates are in clinical trials, including two live-attenuated tetravalent vaccines. They are intended to guide public health professionals and laboratories in the proper administration of the vaccine.

During the first week of an infection, immunoglobulin M antibodies are produced. Neutralizing antibodies are type-specific and persist for years after the virus infection. After the IgM antibodies are produced, type-specific neutralizing antibodies develop. They confer lifelong immunity against the specific serotype of dengue virus. This is the best way to prevent the disease and spread.

Takeda Pharmaceutical Company Limited, declared the approval of their dengue vaccine TAK-003 by European Medicines Agency in March 2021. This vaccine prevents from outbreaks in individuals from 4 to 60 years of age, and the company is planning to apply these approvals in Columbia, Malaysia, Thailand, Argentina, Mexico, Brazil, Sri Lanka, Indonesia and Singapore in 2021.

 

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