Organ-On-A-Chip is a Multi-Channel 3-D Microfluid Cell Culture Ship Which Stimulates Mechanisms, Activities and Physiological Responses In Organs

 

Organ-On-A-Chip

Biological organ-on-a-chip (OoC) systems combine microfluidics with biology. The chip contains engineered tissues and cells that mimic key aspects of human physiology, enabling multi-parametric readouts of organ function. This technology has gained widespread interest as a next-generation experimental platform. OoCs are used in a range of applications, including drug research, drug testing, and diagnostics. Using OoCs, scientists can study the interactions of various aetiological factors, including genetic factors, environmental factors, and systemic crosstalk. These systems can also serve as effective mimics of human disease.

According to Coherent Market Insights the Organ-on-a-chip Market Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2022-2028.

An OoC system enables the study of interactions between organs and between organ and environmental factors. It provides a human-specific experimental platform. A multi-organ system can be designed to mimic the systemic distribution of blood flow, metabolites, and signalling molecules between different organs. These devices can also be used to study the interaction of various aetiological factors, such as drugs, environmental factors, and systemic crosstalk. The design of an OoC system depends on the desired functionalities and application. The complexity of the system can vary from relatively simple to very complex, depending on the desired functionalities and applications.

The two main types of OoCs are single- and multi-organ. Single-organ OoCs are more biologically detailed models of a particular organ, while multi-OoCs include several different organs. A single-organ system can be a useful platform for study of a single organ's functions, or can be used to evaluate the effects of a therapeutic agent. A multi-OoC is used for studies on organ-organ interactions, as well as to evaluate the effects of drugs and other agents.

Multi-OoC systems have been used to study the drug metabolism and immune system of the liver. They also were used for drug testing and toxicity testing. These systems are usually constructed from glass, plastics, and thermoplastics. Some devices have been developed to include integrated fluidic circuitry, microcantilevers, and microwell arrays.

Another component of the system was a pumping system. The system included an air pressure-controlled valve, which recirculated the medium. It also included an integrated fluidic circuitry to mimic the flow of fluids through the device. Another component of the system was a flowing microsystem, which was used to transport the drug molecules from the drug receptor to the basolateral channel

Emulate Inc., declared the novel applications of their of adeno-associated virus transduction used during liver chip in September 2022. This will help researchers in testing the efficacy and safety of adeno-associated virus vectors. This will also help in optimizing gene therapy and also accelerate their development.